International Projects

1. EUTOS for CML (European Treatment and Outcome Study for CML, European LeukemiaNet - ELN)

• Our laboratory is the EUTOS laboratory and reference laboratory for the Czech Republic.
• We provide the validation of conversion factor to harmonize the quantification of BCR-ABL1 transcript in the Czech and Slovak Republics when reporting results on the International Scale.

2. EUTOS-MR (EUTOS for CML III, Path to cure CML; ELN)

• Our laboratory is an EUTOS MR4.5 laboratory; we provide the standardized measurement of major molecular response.
• We participate in defining and standardizing the monitoring of deep molecular response (MR^4.0, MR^4.5, MR^5.0).

3. CAMN107AIC05 - A prospective, randomized, open label two arm Phase III study to evaluate treatment free remission (TFR) rate in patients with Philadelphia-positive CML after two different durations of consolidation treatment with nilotinib (Novartis)

• We perform molecular monitoring of the BCR-ABL1 transcript level on the International Scale and BCR-ABL1 kinase domain mutation analyses of patients from three EU countries.
• Within this study we participate in defining of the deep molecular response.

4. EURO-SKI; EUROpean Stop TKI 

• As an EUTOS MR4.5 laboratory, we perform the monitoring of the deep molecular response in all patients involved in the study from the Czech Republic.

5. EUREKA; European survey on the assessment of deep molecular response in chronic phase CML patients after at least two years of therapy with tyrosine kinase inhibitors (EUTOS for CML, ELN)

• Our laboratory is the principal investigator of the project for the Czech Republic.
• We perform the monitoring of the deep molecular response in patients involved in this study from three hematology centres in the Czech Republic.